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Upregulation of IL-8 and VEGF have also been postulated to contribute to the development of resistance to chemotherapeutic agents in melanoma (89)

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The implications of centrally produced, neuromodulatory GLP-1 in the context of GLP-1RAs are uncertain, as the degree to which signals from pre-proglucagon neurons/endogenous GLP-1 system and GLP-1RA activity converge on shared downstream targets is unclear 6 and may in fact occur independently 7